Every game is big in the NFL, but some just get hyped more than others.

From playing the reigning league MVP in London to a rivalry game on Thanksgiving Day, the Giants' 2022 schedule has it all. Here are five intriguing games to circle this season:

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Week 1: Giants at Titans

Last meeting: Dec. 16, 2018

The Joe Schoen-Brian Daboll era officially begins on the road in an inter-conference matchup. Facing an AFC team makes sense for the first-year general manager and head coach, who came up through the ranks largely on the other side of the league. While they won back-to-back division titles during their time in Buffalo, Mike Vrabel's Titans did the same in the AFC South. The Bills and Titans split wins and losses in their four games against each other during Schoen's and Daboll's tenure as Buffalo's assistant general manager and offensive coordinator, respectively.

Week 2: Giants vs. Panthers

Last meeting: Oct. 24, 2021

The home crowd will see the 2022 Giants for the first time in Week 2. This is the second consecutive year they welcome the Panthers to MetLife Stadium, where the Giants defeated them 25-3 in Week 7 last season. The two teams were also in close contact this offseason. While the Giants held the fifth and seventh overall picks, the Panthers picked sixth. Knowing either Evan Neal or Ikem Ekwonu, two coveted offensive tackles, would be available at No. 7, the Giants took edge rusher Kayvon Thibodeaux at No. 5. Carolina then selected Ekwonu at No. 6, paving the way for Neal to land with the Giants. All three rookies look to be major factors right away for their respective franchises, and they'll come together on Sept. 18.

Week 5: Giants vs. Packers (London)

Last meeting: Dec. 1, 2019

The reach of the National Football League goes beyond one nation.

The league announced that 10 teams will play international games during the 2022 season. The Giants are one of them and will travel to London for the third time to face the Packers in their first game overseas. The Giants won their previous two trips across the Pond – 2007 against the Dolphins and 2016 vs. the Rams. This year, the NFL will also return to Mexico City and play its first-ever game in Germany.

As part of the NFL's 17-game schedule, each team is required to stage at least one international game every eight years. Beginning with the 2022 season, up to four of the teams from the conference whose teams were eligible for a ninth regular-season home game would instead be designated to play a neutral-site international game each year.

There have been 40 regular-season international games in NFL history entering 2022 -- 30 in London, six in Toronto, and four in Mexico City.

The Giants will not go on their bye following the game. Rather, they return home to host the Baltimore Ravens in Week 6. We'll see what defensive coordinator Wink Martindale has dialed up for his former team. The Giants' bye this year is Week 9 after back-to-back road trip to Jacksonville and Seattle. The Giants return from the break with consecutive home games against Houston and Detroit.

Week 11: Giants vs. Lions

Last meeting: Oct. 27, 2019

If you like seeing young talent, this is your game. The Week 11 matchup will feature four of the top 12 selections in last month's draft. In addition to the Giants' selections of Thibodeaux and Neal, the Lions boast edge rusher Aidan Hutchinson, the second overall pick, and Jameson Williams, the record-setting receiver from Alabama who was selected 12th despite suffering a knee injury in last year's national championship game.

Week 12: Giants at Cowboys (Thanksgiving)

Last meeting: Dec. 19, 2021

The Giants will play on Thanksgiving Day for the first time since a night game in Washington in 2017. It will be just their fifth Thanksgiving Day game since 1940 (1982 in Detroit, 1992 in Dallas, 2009 in Denver, and 2017 in Washington). They are 7-5-3 overall on the holiday. Meanwhile, it will be the second leg of the season series against the Cowboys, who won the NFC East a year ago. The rivals first meet on "Monday Night Football" in Week 3.