INDIANAPOLIS – Notes and statistics from the Giants' 28-27 loss to the Indianapolis Colts in Lucas Oil Stadium.

*The Giants lost their second straight game and fell to 5-10. They will conclude their season next week with a home game against the NFC East champion Dallas Cowboys.

*The Giants finished 3-5 on the road, with victories in Houston, San Francisco and Washington.

*They were 1-3 against the AFC South, defeating the Texans.

*The Colts scored the game-winning points with 55 seconds remaining when Andrew Luck threw a one-yard touchdown pass to wide receiver Chester Rogers. It was the third time this season the Giants lost a road game when the opposition scored the deciding points in the final minute. On Oct. 7, Carolina's Graham Gano kicked a 63-yard field goal with one second remaining to give the Panthers a 33-31 victory. And on Nov. 25, Philadelphia's Jake Elliott kicked a 43-yard field goal with 22 seconds left to give the Eagles a 25-22 triumph. The Chicago Bears scored a touchdown as time expired in the fourth quarter on Dec. 2, but the Giants rallied to win in overtime.

*This was the Giants' first one-point loss since Nov. 15, 2015, when they were defeated at home by the New England Patriots, 27-26.

*The Giants scored a touchdown on their first offensive series when Saquon Barkley ran the ball into the end zone from one yard out with 8:11 remaining in the first quarter. It was the Giants' fifth opening-possession touchdown of the season. Barkley scored four of them, on runs at Houston and vs. the Colts, and on receptions vs. Tampa Bay and at Philadelphia. The Giants are 2-3 this season when they score a first-possession touchdown.

*The Giants scored again when they next had the ball on Eli Manning's three-yard touchdown pass to Scott Simonson. It was the second game this season in which the Giants concluded each of their first two offensive series with touchdowns. On Nov. 18 vs. Tampa Bay, Barkley accounted for both scores, first on a six-yard reception, and then on a five-yard run.

*The Giants led after one quarter, 14-0, their largest advantage entering the second period since Dec. 7, 2014 when they led the Titans in Tennessee, 17-0.

*The Giants tied their season-high with 22 first downs, a figure they also reached vs. New Orleans on Sept. 30.

*The Giants' offense did not allow a sack for the first time since Dec. 10, 2017 against Dallas. The unit had allowed one sack twice, in road games at Carolina and San Francisco.

*Indianapolis rushed for 49 yards, the lowest total by a Giants opponent since the Denver Broncos ran for 46 yards on Oct. 15, 2017.

*The Colts finished with 353 net passing yards, the third Giants opponent to exceeded 350 yards through the air this season. The others were Houston (368) and Tampa Bay (359).

*Indianapolis' 27 first downs were the second-highest total for a Giants opponent this season; the Buccaneers had 31 on Nov. 28.

*Eli Manning completed 25 of 33 passes for 309 yards, one touchdown, and one interception (on his final throw of the game), for a passer rating of 101.7. It was Manning's fourth 300-yard passing game of the season and the 49th of his career (regular season). The Giants are 19-30 when Manning throws for at least 300 yards. They have lost their last seven games when he's reached that milestone, last winning on Oct. 16, 2016 against Baltimore.

*Manning scored the seventh rushing touchdown of his 15-year career on a one-yard run in the third quarter. The score gave the Giants a 24-14 lead. Six of Manning's seven rushing touchdowns, including each of the last four, have been on the road. This was his fourth touchdown run that covered one yard. It was the third time Manning also threw a touchdown pass when rushing for a touchdown. The Giants are 4-3 when Manning runs for a touchdown.

*Manning fell to 0-4 against the Colts, one of just two NFL teams he has never beaten as a starting quarterback. The other is the Chargers, who drafted him with the first overall selection in the 2004 NFL Draft before trading him to the Giants.

*Saquon Barkley rushed for 43 yards on 21 carries – his longest run was six yards – and caught five passes for 34 yards. His 77 yards from scrimmage marked the second game in a row and third time this season he was held under 100.

*Barkley needs 114 yards in the Giants' final game to become the third rookie in NFL history with 2,000 yards from scrimmage. Barkley has more receiving yards than Eric Dickerson or Edgerrin James had in their debut seasons, but not as many rushing yards.

*Barkley's 1,198 rushing yards leave him ninth on the franchise's single-season list with one game to play.

*Barkley's five catches increased his season total to a team-high 87. He needs two receptions against Dallas to set an NFL record for catches by a rookie running back. Reggie Bush holds the mark with 88 receptions for New Orleans in 2006.

*Barkley needs five catches to break Odell Beckham, Jr.'s Giants rookie record of 91, set in 2014.

*Barkley's one-yard touchdown run on the Giants' first possession was his 10th on the ground this season. That tied the Giants' record for a rookie running back; Bill Paschal ran for 10 touchdowns in 1943. This is the 12th time in Giants history a Giants back has reached double-digit rushing touchdowns in a season. Barkley is the seventh different player to accomplish the feat, and the first since Brandon Jacobs ran for 15 scores in 2008.

*Wide receiver Sterling Shepard – who did not start for the first time this season - and tight end Evan Engram led the Giants with six catches apiece. Shepard gained 113 yards, his second 100-yard game of the season. He had a career-high 167 yards at Atlanta on Oct. 22.

*The 100-yard game was the first by a Giants receiver since Odell Beckham, Jr. had 136 receiving yards vs. Washington on Oct. 28. It was Shepard's sixth career 100-yard game. The Giants are 1-5 in those games.

*Shepard had a 55-yard reception that set up the Giants' second touchdown. That tied Indianapolis receiver T.Y. Hilton for the game's longest play and was Shepard's second-longest catch of the season; he had a 58-yarder vs. the Falcons.

*Shepard's 90 first-quarter receiving yards were the most by a Giants player since Odell Beckham, Jr. had 98 in the opening period at Tennessee on Dec. 7, 2014.

*Engram gained a season-high 87 yards on his six catches. His previous best was 77 yards at Washington on Dec. 9.

*Bennie Fowler made his fourth start of the season at wide receiver and caught one pass for a season-long 26 yards.

*Simonson caught a career-high three passes for 16 yards, including a three-yarder for his first career touchdown. He totaled four receptions in the first 14 games. Simonson is the 54th different player to catch a regular-season touchdown pass from Manning.

*Wide receiver Cody Latimer, activated off injured reserve last week, played for the first time since Oct. 11 against Philadelphia and had one 10-yard catch.

*The Giants' first offensive play was a five-yard run by wide receiver Corey Coleman. It was Coleman's first rushing attempt since Jan. 2, 2017, when he gained nine yards for Cleveland at Pittsburgh in the final game of his rookie season.

*Shepard also had a rushing attempt, but lost three yards. This was the first Giants game in which two wide receivers each had rushing attempts since Nov. 28, 2004, in Manning's second career start. In a game vs. Philadelphia in Giants Stadium, Ike Hilliard gained 17 yards and Jamaar Taylor lost eight yards running the ball.

*Not to be outdone, Engram also ran the ball, twice for 26 yards. It was the second game this season in which a wide receiver and Engram each had rushing attempts. On Oct. 22 in Atlanta, Beckham lost a yard on his only rushing attempt, and Engram had a 10-yard run.

*John Greco started and played the entire game at center. It was his seventh start of season, his fifth at center, and first at that position since Oct. 11.

*Rookie linebacker Tae Davis started his third game of the season and led the Giants with seven tackles (six solo) and had the game's only sack, a four-yard takedown of Andrew Luck.

*Safety Curtis Riley picked off a Luck pass for his fourth interception of the season, one behind team leader Alec Ogletree.

*Aldrick Rosas kicked field goals of 40 and 27 yards and has now made 30 of 31 attempts this season a .968 percentage. Rosas has converted 18 consecutive attempts, the longest streak by a Giants kicker since Josh Brown made 29 straight spanning the 2014-2015 seasons.

*Luck joined Houston's Deshaun Watson and Atlanta's Matt Ryan as the only quarterbacks to throw for more than 300 yards against the Giants this season.

*Hilton caught eight passes for a game-high 138 yards, the second-highest total by a Giants opponent this year. Chicago running back Tarik Cohen had 156 yards on Dec. 2.

*Defensive lineman Mario Edwards left the game in the first quarter with a calf injury, and tight end Rhett Ellison departed in the third quarter with a concussion.

*The Giants are now 32-36 in regular-season indoor games.

*The Colts won for the eighth time in nine games after a 1-5 start.

*The Giants inactive players were wide receivers Odell Beckham, Jr. (quad) and Russell Shepard (ankle), linebacker Alec Ogletree (concussion), center Spencer Pulley (calf), defensive lineman Kerry Wynn (thumb), defensive back Kamrin Moore, and quarterback Kyle Lauletta.