Everything you need to know heading into the Week 2 matchup between the Giants and Bills:
1. Home opener. After an unsuccessful trip to Dallas, the New York Giants return to MetLife Stadium this Sunday for their 2019 home opener. They host the AFC East's Buffalo Bills, who last week defeated the New York Jets in a comeback thriller. The Giants have won the last three (in 2007, 2011 and 2015) and four of the last five games in the series against the Bills.
2. Circling the wagons around MetLife. As of Sunday night, the Bills will have played more games in MetLife Stadium than the Giants and Jets this season. Buffalo started the year on the road against the Jets, who jumped out to a 16-0 lead only to have the Bills score 17 unanswered points. Sunday will be the first time a road team has played at the same stadium in consecutive weeks since Baltimore did it in 2016, also at MetLife Stadium.
3. Eli-0. Quarterback Eli Manning is 3-0 vs. Buffalo, one of four teams he has a perfect record against as a starter. He is 4-0 vs. Houston, 3-0 vs. Miami and 3-0 vs. Oakland. Manning last met the Bills on Oct. 4, 2015, in Buffalo, where he threw three touchdown passes in a 24-10 Giants victory. They last faced each other in New Jersey on Oct. 16, 2011, when Lawrence Tynes kicked a game-winning 23-yard field goal with 1:32 remaining in a 27-24 Giants victory.
4. Injury report. NYG – Out: WR Sterling Shepard (concussion), WR Darius Slayton (hamstring), TE Garrett Dickerson (quad). Questionable: WR Cody Latimer (calf). BUF – Out: CB Taron Johnson (hamstring), WR Andre Roberts (quad). Questionable: TE Tyler Kroft (foot).
5. Engram's growing importance. With Shepard out and Golden Tate on the second week of a four-game suspension to start the season, tight end Evan Engram again will be a focal point in the passing attack. The third-year pro caught an opening-drive touchdown last week en route to posting career highs in receptions (11) and receiving yards (116).
6. Saquon hundred. Running back Saquon Barkley needs five receptions to tie Carolina's Christian McCaffrey (18 games) as the fastest running backs in NFL history to reach 100 career receptions. Last week, Barkley recorded his 14th game with at least 100 yards from scrimmage. He ran for 120 yards on 11 carries and caught four passes for 19 yards. His first carry was a 59-yard gain in which he reached a speed of 21.76 mph, which was the NFL's fastest by a ball carrier in Week 1, according to Next Gen Stats.
View the best images from the all-time series between the Giants and Bills
Buffalo Bills kicker Scott Norwood, center, misses the field goal on the last play of the game, clinching the victory for the New York Giants in Super Bowl XXV in Tampa Sunday, January 27, 1991. The Giants won 20-19. (AP Photo/Phil Sandlin)
New York Giants' running back Tucker Frederickson (24) tries to make it through a hole in the Buffalo Bill's line during game at New York's Yankee Stadium on Sunday, Dec. 7, 1970. Bills' end Ron McDole (72), coming off a block by New York offensive tackle Dick Buzin (77), tries to plug the hole. Giants guard Doug Van Horn (63) blocks Buffalo middle linebacker Edgard Chandler (52) at right. Fredrickson made gain of 2 yards on the play as New York won, 20-8. (AP Photo)
Joe Danelo of the New York Giants follows through, left, as his kick sails over the outstretched arms of Buffalo Bills players to win Monday, Aug. 29, 1977 exhibition game 24-21 in sudden death overtime in East Rutherford, N.J. The ball is above the jumping Mamo Clark (29) and Sherman White (83) was unable to block it. (AP Photo/RFS)
Running back Rodney Hampton (27) of the New York Giants is spun around as he is face masked by Leon Seals of the Buffalo Bills in the second quarter at Giants Stadium in East Rutherford, N.J., Dec 15, 1990. Hampton gained nine yards and picked up an additional ten yards on the face mask penalty. (AP Photo/Bill Kostroun)
New York Giants Bill Parcells smiles before the start of Super Bowl XXV against Buffalo Bills in Tampa Sunday, Jan. 27, 1991. The Giants beat the Bills 20-19. (AP Photo/Rusty Kennedy)
New York Giants kicker Matt Bahr tackles Don Smith of the Buffalo Bills on the opening kickoff of Super Bowl XXV Sunday, Jan. 27, 1991 in Tampa. (AP Photo/Olga Shalygin)
New York Giant running back Ottis Anderson (24) is brought down the hard way during the fourth quarter of Super Bowl XXV Sunday, Jan. 27, 1991 in Tampa. Anderson was named the game's most valuable player as the Giants defeated the Buffalo Bills, 20-19. (AP Photo/Doug Mills)
Buffalo Bills quarterback Jim Kelly gets sacked during the fourth quarter ny New York Giants linebacker Pepper Johnson. The Giants came out on top to win the Super Bowl 20-19 in Tampa Sunday, Jan. 27, 1991. (AP Photo/Bill Waugh)
New York Giants running back Ottis Anderson (24) carries the ball as he leaps over Buffalo Bills Kirby Jackson during fourth quarter of Super Bowl XXV at Tampa Stadium Sunday, Jan. 27, 1991. Giants Stephen Baker is under Jackson. The Giants defeated the Bills 20-19. (AP Photo/Bill Haber)
Leonard Marchall (70) and Erik Howard (74) of the New York Giants celebrate the sack of Buffalo Bills quarterback Jim Kelly (12) in the third quarter of SUper Bowl XXV Sunday, Jan. 27, 1991 in Tampa. (AP Photo/Lynn Sladky)
Members of the Buffalo Bills hold hands on the sidelines as they watch Scott Norwood attemp a field goal that could've won the Bills Super Bowl XXV. Norwood missed and the New York Giants won 20-19. At left wearing a blue sweater is Bills coach Marv Levy. Wearing a helmet second from right is Bills quarterback Jim Kelly. (AP Photo/Craig Fujii)
New York Giants quarterback Jeff Hostetler (15) celebrates a second quarter touchdown against the Buffalo Bills during Super Bowl XXV in Tampa, Fla., in this Jan. 27, 1991 photo. The Giants, back at the spot where they won the Super Bowl a decade ago, began practice Monday Jan. 22, 2001 for this year's championship against the Baltimore Ravens. (AP Photo)
New York Giants coach Bill Parcells is carried on the shoulders of Lawrence Taylor (56) and Carl Banks (58) after winning the Super Bowl XXV in Tampa, Fla., Sunday, Jan. 28, 1991. The Giants defeated the Buffalo Bills, 20-19. (AP Photo/Ed Reinke)
New York Giants head coach Bill Parcells lets out a yell after being drenched by his team as they defeated the Buffalo Bill, 20-19, in Super Bowl XXV Sunday, Jan. 27, 1991 in Tampa. With Parcells is Carl Banks. (AP Photo/Bill Waugh)
Buffalo Bills kicker Scott Norwood (11) walks off the field in dejection after missing a 47-yard field goal on the last play of the game, clinching a 20-19 victory for the New York Giants in Super Bowl XXV in Tampa, Fla., Jan. 27, 1991. Giants' Reyna Thompson, right, celebrates as Bills holder Frank Reich (14) also leaves the field. (AP Photo/Rusty Kennedy)
New York Giant runningback Ottis Anderson gives the thumb up sign following his team's win 20-19 over Buffalo Bills in Super Bowl XXV in Tampa Sunday, Jan. 27, 1991. (AP Photo/Bill Haber)
New York Giants head coach Bill Parcells celebrates his team's victory over the Buffalo Bills in Super Bowl XXV in Tampa, Fla., Jan. 27, 1991. The Giants won 20-19. (AP Photo/Bill Haber)
Members of the New York Giants and the Buffalo Bill pray together in a circle as they surrounded by members of the media after the Super Bowl in Tampa Sunday, Jan. 27, 1991. The Giants beat the Bills 20-19. (AP Photo/Craig Fujii)
New York Giants head coach Bill Parcells shows off the Super Bowl trophy after his team beat the Buffalo Bills 20-19 in Tampa, Fl., Jan. 28, 1991. (AP photo/Mark Lennihan)
Buffalo Bills quarterback Doug Flutie (7) fumbles as he is taken down by New York Giants defensive end Cedric Jones (94) during the first half of the game at Ralph Wilson Stadium, in Orchard Park, N.Y., Sunday, Dec. 12, 1999. The Giants recovered the fumble that set up a field goal. They went on to beat the Bills 19-17. (AP Photo/Mike Groll)
New York Giants' wide receiver Amani Toomer, left, catches a pass downfield for a touchdown in front of Buffalo Bills' London Fletcher during the second quarter Sunday, Nov. 30, 2003, in East Rutherford, New Jersey. (AP Photo/Julie Jacobson)
Buffalo Bills quarterback Trent Edwards, left, gets a pass off before being tackled by New York Giants safety Michael Johnson, right, during the first half of an NFL football game in Orchard Park, N.Y. on Sunday, Dec. 23, 2007. New York won 38-21. (AP Photo/Don Heupel)
New York Giants' Eli Manning wears a rain coat during the rain and snow during the second half of the NFL football game against the Buffalo Bills at Ralph Wilson Stadium in Orchard Park, N.Y., Sunday, Dec. 23, 2007. (AP Photo/David Duprey)
New York Giants' Osi Umenyiora (72) celebrates a Giants interception and touchdown during the second half of the NFL football game against the Buffalo Bills at Ralph Wilson Stadium in Orchard Park, N.Y., Sunday, Dec. 23, 2007. (AP Photo/David Duprey)
New York Giants' Eli Manning calls a signal before the snap during the NFL football game against the Buffalo Bills at Ralph Wilson Stadium in Orchard Park, N.Y., Sunday, Dec. 23, 2007. (AP Photo/David Duprey)
New York Giants' Brandon Jacobs (27) runs against the Buffalo Bills during the second half of an NFL football game at Ralph Wilson Stadium in Orchard Park, N.Y., Sunday, Dec. 23, 2007. The Giants won 38-21. (AP Photo/Derek Gee)
New York Giants quarterback Eli Manning looks downfield for a receiver during the first half of an NFL football game against the Buffalo Bills in Orchard Park, N.Y. on Sunday, Dec. 23, 2007. New York won 38-21. (AP Photo/Don Heupel)
Buffalo Bills punter Brian Moorman, right, tries to recover his fumble as New York Giants special teams player Ahmad Bradshaw, left, tackles him during the first half of an NFL football game in Orchard Park, N.Y. on Sunday, Dec. 23, 2007. New York won 38-21. (AP Photo/Don Heupel)
New York Giants' Ahmad Bradshaw (44) runs past Buffalo Bills' Terrence McGee (24) for a touchdown during the second half of an NFL football game at Ralph Wilson Stadium in Orchard Park, N.Y., Sunday, Dec. 23, 2007. (AP Photo/Derek Gee)
New York Giants cornerback Corey Webster, right, celebrates his touchdown with teammate safety James Butler, left, after a 34-yard interception against the Buffalo Bills during the second half of an NFL football game in Orchard Park, N.Y. on Sunday, Dec. 23, 2007. New York won 38-21. (AP Photo/Don Heupel)
New York Giants' Brandon Jacobs (27) scores a touchdown under pressure from Buffalo Bills' John DiGiorgio (52) during the second quarter of their NFL football game at Ralph Wilson Stadium in Orchard Park, N.Y., Sunday, Dec. 23, 2007. The Giants won 38-21. (AP Photo/Derek Gee)
Buffalo Bills' Marshawn Lynch (23) is tackled by New York Giants' Antonio Pierce (58) and Aaron Ross (31) during the first quarter of an NFL football game at Ralph Wilson Stadium in Orchard Park, N.Y., Sunday, Dec. 23, 2007. (AP Photo/David Duprey)
New York Giants' Amani Toomer (81) makes a catch under pressure from Buffalo Bills' Jim Leonhard (42) during the first quarter of the NFL football at Ralph Wilson Stadium in Orchard Park, N.Y., Sunday, Dec. 23, 2007. (AP Photo/Derek Gee)
New York Giants quarterback Eli Manning looks to throw during the first quarter of the NFL football game against the Buffalo Bills at Ralph Wilson Stadium in Orchard Park, N.Y., Sunday, Dec. 23, 2007. (AP Photo/David Duprey)
New York Giants' Kawika Mitchell (55) celebrates his interception for a touchdown during the second half of the NFL football game against the Buffalo Bills at Ralph Wilson Stadium in Orchard Park, N.Y., Sunday, Dec. 23, 2007. The Giants won 38-21. (AP Photo/David Duprey)
New York Giants' Ahmad Bradshaw (44) is hit by Buffalo Bills' Bryan Scott (43) during the second half of an NFL football game at Ralph Wilson Stadium in Orchard Park, N.Y., Sunday, Dec. 23, 2007. The Giants won 38-21. (AP Photo/David Duprey)
Buffalo Bills kicker Rian Lindell, far right, kicks a field goal during the second quarter of an NFL football game against the New York Giants on Sunday, Oct. 16, 2011, in East Rutherford, N.J. (AP Photo/Julio Cortez)
New York Giants' Ahmad Bradshaw (44) scores a touchdown over the Buffalo Bills during the third quarter of an NFL football game Sunday, Oct. 16, 2011, in East Rutherford, N.J. (AP Photo/Julio Cortez)
New York Giants cornerback Corey Webster (23) intercepts a pass intended for Buffalo Bills wide receiver Steve Johnson during the fourth quarter of an NFL football game on Sunday, Oct. 16, 2011, in East Rutherford, N.J. Johnson was called for a face mask on the play. The Giants won the game 27-24. (AP Photo/Bill Kostroun)
New York Giants' Corey Webster (23) is helped up by teammates after intercepting a pass during the fourth quarter of an NFL football game against the Buffalo Bills Sunday, Oct. 16, 2011, in East Rutherford, N.J. The Giants won the game 27-24. (AP Photo/Kathy Willens)
New York Giants' Ahmad Bradshaw is interviewed at the completion of an NFL football game between the New York Giants and the Buffalo Bills Sunday, Oct. 16, 2011, in East Rutherford, N.J. The Giants won the game 27-24. (AP Photo/Julio Cortez)
Buffalo Bills quarterback Ryan Fitzpatrick, left, greets New York Giants quarterback Eli Manning after an NFL football game on Sunday, Oct. 16, 2011, in East Rutherford, N.J. The Giants won the game 27-24. (AP Photo/Bill Kostroun)
New York Giants running back Ahmad Bradshaw (44) dives past Buffalo Bills free safety Jairus Byrd (31) and Nick Barnett (50) for a touchdown during the third quarter of an NFL football game on Sunday, Oct. 16, 2011, in East Rutherford, N.J. (AP Photo/Julio Cortez)
New York Giants' Brandon Jacobs, right, celebrates with Mario Manningham during the third quarter of an NFL football game against the Buffalo Bills Sunday, Oct. 16, 2011, in East Rutherford, N.J. (AP Photo/Bill Kostroun)
New York Giants' Eli Manning (10) looks to pass as Buffalo Bills' Marcell Dareus (99) rushes him during the fourth quarter of an NFL football game Sunday, Oct. 16, 2011, in East Rutherford, N.J. The Giants won the game 27-24. (AP Photo/Julio Cortez)
Buffalo Bills quarterback Ryan Fitzpatrick, center, looks to pass as New York Giants defensive tackle Chris Canty (99) and Osi Umenyiora (72) rush the passer during the second quarter of an NFL football game Sunday, Oct. 16, 2011, in East Rutherford, N.J. (AP Photo/Julio Cortez)
Buffalo Bills quarterback Ryan Fitzpatrick (14) is sacked by New York Giants defensive end Jason Pierre-Paul (90) and Dave Tollefson (71) during the second quarter of an NFL football game on Sunday, Oct. 16, 2011, in East Rutherford, N.J. (AP Photo/Julio Cortez)
MetLife Stadium is filled with spectators during the third quarter of an NFL football game between the New York Giants and the Buffalo Bills Sunday, Oct. 16, 2011, in East Rutherford, N.J. (AP Photo/Julio Cortez)
Buffalo Bills quarterback Ryan Fitzpatrick, bottom, reacts after being sacked by New York Giants outside linebacker Mathias Kiwanuka (94) during the second quarter of an NFL football game on Sunday, Oct. 16, 2011, in East Rutherford, N.J. (AP Photo/Julio Cortez)
New York Giants' Hakeem Nicks (88) and Buffalo Bills' Terrence McGee (24) run in the end zone during an incomplete pass during the second quarter of an NFL football game Sunday, Oct. 16, 2011, in East Rutherford, N.J. (AP Photo/Bill Kostroun)
Buffalo Bills quarterback Ryan Fitzpatrick (14) walks back to the sideline during the fourth quarter of an NFL football game against the New York Giants on Sunday, Oct. 16, 2011, in East Rutherford, N.J. The Bills lost the game 24-27. (AP Photo/Bill Kostroun)
New York Giants running back Ahmad Bradshaw (44) runs past Buffalo Bills cornerback Drayton Florence (29) during the first quarter of an NFL football game on Sunday, Oct. 16, 2011, in East Rutherford, N.J. (AP Photo/Julio Cortez)
New York Giants wide receiver Rueben Randle (82) reacts after scoring a touchdown on a pass from quarterback Eli Manning as Buffalo Bills cornerback Stephon Gilmore, left, and strong safety Bacarri Rambo look on during the first half of an NFL football game, Sunday, Oct. 4, 2015, in Orchard Park, N.Y. (AP Photo/Bill Wippert)
New York Giants running back Rashad Jennings, right, looks at Buffalo Bills cornerback Ronald Darby, left, as he scores on a touchdown run during the second half of an NFL football game, Sunday, Oct. 4, 2015, in Orchard Park, N.Y. (AP Photo/Gary Wiepert)
New York Giants quarterback Eli Manning (10) talks to his teammates during the first half of an NFL football game against the Buffalo Bills, Sunday, Oct. 4, 2015, in Orchard Park, N.Y. (AP Photo/Bill Wippert)
7. Giants bring back TJ Jones. The Giants this week re-signed wide receiver TJ Jones, who led them in catches in the preseason but was released in the roster cut on August 31. The team created room on the roster by placing linebacker Kareem Martin on injured reserve. Martin, who played all 16 games last season, suffered a knee injury in Dallas. Jones, who spent his first four seasons in Detroit, is also an option as a return specialist.
8. Picking up the D. The Giants failed to record a sack or force a turnover last week against the Cowboys. The result was a loss for Big Blue and a perfect 158.3 passer rating for Dak Prescott, the first of its kind against the Giants with a minimum 20 pass attempts. The Giants have lost their last 11 games in which they did not force a turnover.
On the other side, Buffalo has held nine consecutive opponents to less than 210 passing yards, their longest streak since 2004 and the NFL's longest since Seattle's streak of 13 games in a row from 2013-14.
9. Next up: Josh Allen. The defense's next challenge is taking down second-year quarterback Josh Allen, who leads all players at his position in rushing touchdowns (nine) and 10-yard runs (24) since he was drafted seventh overall in 2018. The Bills are 6-1 when the former seventh overall draft pick has a rushing touchdown; they are 0-6 when he does not. The good news for Giants fans is that Allen has the third-highest interception rate (3.9% of pass attempts) in the NFL (minimum 224 attempts) since he came into the league. Ryan Fitzpatrick (4.7) is first, Jameis Winston (4.1) is second and Josh Rosen (3.8) is fourth.
10. Fantennial Kickoff. The NFL is continuing its centennial celebration with local team Fantennial Weekends. Dozens of Giants alumni will be celebrated on-field during Sunday's game, including a special halftime ceremony when the Giants will reveal the greatest moment in franchise history.
Giants vs. Bills Broadcast Info: TV channel, Radio Station and Live Stream.
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