Giants defensive end Mathias Kiwanuka did not make the trip with the team to Jacksonville in advance of the Week 13 matchup with the Jaguars.
The ninth-year veteran, who has not missed a regular-season game since 2010, was questionable heading into the game with a knee injury. He joins offensive lineman Adam Snyder (knee), linebacker Jacquian Williams (concussion/shoulder), and defensive tackle Cullen Jenkins (calf) as Giants who are ruled out for Sunday because of injuries.
The full inactives list will be announced 90 minutes prior to the 1 p.m. ET kickoff.